Most every system within the human body contains antagonistic autonomic sympathetic and autonomic parasympathetic nerve fibers which are essential for the regulation of a plethora of physiologic functions, including, importantly, the regulation of blood flow. Using the dental pulp as an example, 10% of the pulp consists of 3rd order, unmyelinated autonomic sympathetic fibers (influencing both nociception and blood perfusion), whilst 90% of the dental pulp consists of a delta, a beta, and c fibers of trigeminal sensory origination (influencing both nociception and/or proprioception).The dental pulp has never been shown histologically to possess parasympathetic fibers to counter its sympathetic innervation (unlike most other parts of the human body), which can lead to many undesirable outcomes, such as the need for endodontic therapy following routine restorative procedures, incomplete lower IAN blocks, dry sockets, dystonia of muscles, and much more. Ramping down sympathetic inflow to the maxillofacial region via the initiation of 3rd order sympathetic blocks utilizing local anesthetic, can often PREVENT the aforementioned problems from occurring. 3rd order blocks prevent excessive vasoconstriction, leading to better blood perfusion within the pulp, alveolar bone, masticatory muscles, the TM joint, and the periodontium. Very few general or specialty practitioners are even aware of the aforementioned facts which are extremely relevant to many confounding issues that are routinely faced by them in everyday practice, and are oblivious to the havoc that the influence that these autonomic  sympathetic nerve fibers can have upon operative, surgical, muscular, orthopedic, endodontic, orthodontic and periodontal conditions. As CNO6 demonstrates, it turns out that there are MASSIVE influences on not only the health of the dental pulp, but also upon the periodontium, alveolar bone, muscles, & the TMJs; essentially the entire masticatory system. Additionally, the CNO has recently published novel clinical research showing that the usage of local anesthetic targeting 3rd order neurons in the neck leads to consistent anxiolysis; finally-a simple cure for procedural anxiety is here (Piper, Yiannios & Radke, 2026)!